First, of course I'm picking the Jayhawks! See the header.
Second, there have to be a few upsets here and there. Gonzaga is the best starting point, and Nate Silver and gang at 538 are full of shit if they think the Zags have the best odds of getting to the Final Four of any team. So, that one's not really an upset.
SMU seems to be peaking at the right time, in the East, and the Dookies still seem a bit fragile.
Roy Williams seems to have righted the Heels' ship, and I see the WuShocks as underrated, but not to get all the way to the final weekend.
Related to the upset potential? The Ponies in the Final Four, without Larry Brown as coach but perhaps still benefiting from Larry Brown's cheating, would be a fun side story.
OK, if I'm right this far?
Great semifinal No. 1. Another rematch of Heels and ’Hawks. Huggins, on the other side, strangles the Ponies in the crib with his patented press.
Jayhawks, unfazed by that and led by Frank Mason III, win!